show that fish oil supplementation at either low or high dosages has no effect on the lifespan of male or female mice.
Using a large cohort of genetically heterogeneous mice in three sites, part of the Interventions Testing Program of the NIA, Strong et al. challenges the role for fish oil supplementation in aging. Could fish oil and its omega-3 fatty acids act as geroprotectors? Probably not. Initial results from short-lived mouse strains showed that fish oil can increase lifespan, affecting pathways like inflammation and oxidation thought to be involved in the regulation of aging. Its anti-inflammatory properties have also been reported. Fish oil supplementation is of great medical and public interest with epidemiological evidence of health benefits in humans, in particular by conferring protection against heart diseases.
